Background- Coronary artery bypass grafting (CABG) is a common surgical procedure performed in the world. Coronary artery disease (CAD) has become prevalent in Iran, and the aim of this study is to assess the effects of CABG on LV systolic and diastolic function indices. We also attempted to disclose the CABG effect on the myocardial performance (Tei) index.Methods- 50 patients were enrolled in this study, all of whom were given instructions about the research program. They were admitted to our center electively for CABG; the first echocardiography was taken just prior to surgery, and the second TTE was performed between 1 and 43 weeks after surgery (mean=11 weeks).Results- CABG had dramatic effects on the patients, as their mean left ventricular ejection fraction (LVEF) rose from 48.88% to 52.54% (P<0.001). It was more obvious in patients with preoperative LVEF less than 40%, Tei index<0.49, male gender and those with complete revascularization. LVEF had no change in the case of incomplete revascularization. MPI (Tei) decreased significantly after CABG from 0.4992 to 0.4462 (P=0.001), which was more pronounced in those whose preoperative Tei index was equal or more than 0.49 and in patients with triple vessel or left main CAD. Diastolic function recovery had a time-dependent manner with no change or even deterioration during the first few days after CABG, but after 4 weeks nearly half of the patients had normal diastolic function. History of systemic hypertension and old age (>60 years old) are both associated with more preoperative diastolic dysfunction and are negative predictors for diastolic function recovery after CABG. Isovolumetric relaxation time (IVRT), E-wave deceleration time (EDT), peak E-wave velocity (PEV) and peak A-wave velocity (PA) all show significant improvement after CABG. There was no mortality in our series.Conclusion- CABG has important positive and significant effects on many LV systolic and diastolic indices including LVEF, LVESV, IVRT, PEV, PAY and EDT as well as on the myocardial performance (Tei) index.

Background: The myocardial performance index (MPI), also known as the Tei index, was introduced by Tei et al. to evaluate cardiac function in adults with dilated cardiomyopathy. This index is defined as the sum of isovolumic contraction time (ICT) and isovolumic relaxation time (IRT), divided by ejection time (ET).Objectives: To determine the correlation between pulsed doppler (Pd) - and tissue doppler imaging (TdI) -derived Tei indices in fetuses. Patients and Methods: Right and left ventricle Pd and TdI echocardiographic data were obtained from 59 fetuses (11 pregnant women who were positive for anti-SSA-Ro or anti-SSB-La antibodies, 18 women who were referred due to dysrhythmia, and 30 women who had normal clinical findings).Results: Mean fetal gestational age was 27±6.4 weeks. Mean Pd Tei index of the mitral and tricuspid valve was 0.58±0.05 and 0.53±0.08, respectively. Mean TdI indices for the mitral and tricuspid valve were 0.56±0.09 and 0.55±0.08, respectively. There were no significant differences between mitral and tricuspid Pd- and TdI-derived Tei indices (P=0.87, P=0.21), but the Bland-Altman diagrams showed no fine agreement between the indices (the mean difference ±1 standard deviation of the right ventricular Pd- and TdI-derived Tei indices was 0.24±0.02 and 0.29±0.04 for the left ventricle). There were no significant differences in Pd- and TdI-derived Tei indexes between groups of evaluated fetuses (Mitral valve: Pd-Tei P=0.69, TdI-Tei P=0.49; Tricuspid valve: Pd-Tei P=0.41, TdI-Tei P=0.36).Conclusions: Although the mean values of the two indices did not differ significantly, the TdI-derived and Pd-derived Tei indices did not have fine agreement.

Introduction: Cardiac complications, including heart failure, are the most important secondary ones of the thalassemia major disease, which manifests itself in adolescence and early adulthood. Appropriate, low cost diagnostic tools available as well as knowing its related factors are the most important components of therapy in these patients, given the importance of these complications, or by examining and revealing early symptoms. Thus, in this study, we intend to examine the systolic and diastolic ventricular effects in adult patients with the help of Tei index.Methods: 70 adult patients with thalassemia major were examined in this study. Frequency of Tei index and its association with factors such as age, sex, level of packed cell injection, as well as hemosiderosis were measured in two blood levels of more than 1000 ferretins.Results: In this study, 70 youth adult patients with thalassemia major with an average age of 21.3±2.8 years were studied, 31 were male (44.4%). Tei index were abnormal in 16 patients (24%). There is no statistically significant correlation between the Tei index and one of the variables of age, gender, number and duration of blood transfusion and deferoxamine, the hemoglobin level and the number of ferretins (P>0.05).Discussion: Study on Tei index shows that many patients are subclinically involved in the disease before the onset of clinical symptoms of heart failure, the subject which raises the need for early diagnosis of the disease; and it seems that none of the demographic factors or factors related to disease cannot be considered as a main cause or warning of the disease; and the above results can be confirmed only on the basis of paraclinical tests.

Background: Cardiomyopathy usually causes a cardiac dysfunction resistant to treatment due to anthracycline. This study aimed to evaluate the changes in Tei-index (myocardial performance index) in patients with malignancies treated with anthracycline. Material and Methods: This case-control study was done on 15 children who were treated with low-dose anthracycline (1-199mg/kg) called group A and 15 children who were treated with high dose (>200mg/kg) anthracycline called group B after acquiring consent from their parents. Children with no abnormality in Echo-Doppler results were included in this study. The patients’ age range between 1-17 years with a mean age of 6. 57 years. Another group of healthy children were assigned to group C as a control group who had not received chemotherapy. The first echo was performed right before the treatment and the second one, two weeks after completing chemotherapy. Data were analyzed by the SPSS statistical software. Results: Changes in mean Tei-index in group A were 0. 36 ± 0. 04 before treatment and 0. 43 ± 0. 11 after treatment. Changes in mean Tei-index in group B were 0. 37 ± 0. 04 before treatment and 0. 45 ± 0. 06 after treatment. There was no significant difference between the two groups using the independent T-test. (p-value= 0. 57). No significant correlation between the changes in mean ejection fraction (EF) and treatment was found in the three groups (p-value=0. 45). Conclusion: This study showed a change in the Tei-index (MPI) in patients receiving anthracycline; regardless of the dosage, they got in their regimen. Given the use of anthracycline, any abnormal cardiac finding can alert the physicians to the possibility of cardiomyopathy, hence scheduling routine follow-ups are necessary.